| South San Francisco to University Place (Washington) | 660.63 mi (1,063.17 km) |
| South San Francisco to Upland (California) | 361.38 mi (581.58 km) |
| South San Francisco to Upper Arlington (Ohio) | 2,106.77 mi (3,390.51 km) |
| South San Francisco to Upper Grand Lagoon (Florida) | 2,151.23 mi (3,462.07 km) |
| South San Francisco to Upper Montclair (New Jersey) | 2,556.83 mi (4,114.82 km) |
| South San Francisco to Urbana (Illinois) | 1,837.08 mi (2,956.50 km) |
| South San Francisco to Urbana (Maryland) | 2,415.07 mi (3,886.68 km) |
| South San Francisco to Urbana (Ohio) | 2,070.19 mi (3,331.64 km) |
| South San Francisco to Urbandale (Iowa) | 1,540.92 mi (2,479.87 km) |
| South San Francisco to Utica (New York) | 2,479.25 mi (3,989.96 km) |
| South San Francisco to Uvalde (Texas) | 1,424.90 mi (2,293.15 km) |
| South San Francisco to Vacaville (California) | 54.57 mi (87.83 km) |
| South San Francisco to Vadnais Heights (Minnesota) | 1,595.24 mi (2,567.30 km) |
| South San Francisco to Vail (Arizona) | 769.57 mi (1,238.51 km) |
| South San Francisco to Valdosta (Georgia) | 2,267.24 mi (3,648.78 km) |
