| South San Francisco to Yonkers (New York) | 2,572.52 mi (4,140.06 km) |
| South San Francisco to Yorba Linda (California) | 368.09 mi (592.38 km) |
| South San Francisco to York (Pennsylvania) | 2,438.05 mi (3,923.66 km) |
| South San Francisco to Yorktown (Indiana) | 1,977.44 mi (3,182.39 km) |
| South San Francisco to Yorkville (Illinois) | 1,816.04 mi (2,922.63 km) |
| South San Francisco to Youngstown (Ohio) | 2,222.34 mi (3,576.51 km) |
| South San Francisco to Youngsville (Louisiana) | 1,812.56 mi (2,917.03 km) |
| South San Francisco to Ypsilanti (Michigan) | 2,061.33 mi (3,317.39 km) |
| South San Francisco to Yuba City (California) | 110.79 mi (178.29 km) |
| South San Francisco to Yucaipa (California) | 391.34 mi (629.81 km) |
| South San Francisco to Yucca Valley (California) | 414.85 mi (667.63 km) |
| South San Francisco to Yukon (Oklahoma) | 1,371.81 mi (2,207.71 km) |
| South San Francisco to Yulee (Florida) | 2,366.62 mi (3,808.71 km) |
| South San Francisco to Yuma (Arizona) | 565.11 mi (909.45 km) |
| South San Francisco to Zachary (Louisiana) | 1,841.69 mi (2,963.91 km) |
