| South Valley to Sacile | 5,682.83 mi (9,145.63 km) |
| South Valley to Sala Consilina | 6,065.16 mi (9,760.93 km) |
| South Valley to Salemi | 6,086.45 mi (9,795.20 km) |
| South Valley to Salerno | 6,020.52 mi (9,689.09 km) |
| South Valley to Salo | 5,631.07 mi (9,062.33 km) |
| South Valley to Salsomaggiore Terme | 5,647.78 mi (9,089.23 km) |
| South Valley to Saluzzo | 5,564.08 mi (8,954.52 km) |
| South Valley to Salzano | 5,690.16 mi (9,157.43 km) |
| South Valley to Samarate | 5,567.45 mi (8,959.94 km) |
| South Valley to San Benedetto del Tronto | 5,877.36 mi (9,458.70 km) |
| South Valley to San Biagio di Callalta | 5,692.10 mi (9,160.54 km) |
| South Valley to San Bonifacio | 5,667.11 mi (9,120.33 km) |
| South Valley to San Casciano in Val di Pesa | 5,745.93 mi (9,247.18 km) |
| South Valley to San Cataldo | 6,148.59 mi (9,895.20 km) |
| South Valley to San Cesareo | 5,893.02 mi (9,483.90 km) |
