| Southampton to Orbetello | 834.34 mi (1,342.74 km) |
| Southampton to Oria | 1,160.55 mi (1,867.73 km) |
| Southampton to Oristano | 899.54 mi (1,447.66 km) |
| Southampton to Orta Nova | 1,048.87 mi (1,687.99 km) |
| Southampton to Orte | 873.54 mi (1,405.82 km) |
| Southampton to Ortona | 951.37 mi (1,531.09 km) |
| Southampton to Orvieto | 850.95 mi (1,369.47 km) |
| Southampton to Orzinuovi | 645.12 mi (1,038.23 km) |
| Southampton to Osimo | 864.18 mi (1,390.76 km) |
| Southampton to Ospitaletto | 643.50 mi (1,035.61 km) |
| Southampton to Ostuni | 1,147.41 mi (1,846.57 km) |
| Southampton to Ottaviano | 1,028.52 mi (1,655.24 km) |
| Southampton to Ovada | 635.45 mi (1,022.65 km) |
| Southampton to Ozieri | 869.96 mi (1,400.07 km) |
| Southampton to Paceco | 1,123.23 mi (1,807.66 km) |
