| Southampton to Sacile | 721.28 mi (1,160.79 km) |
| Southampton to Sala Consilina | 1,091.18 mi (1,756.09 km) |
| Southampton to Salemi | 1,140.30 mi (1,835.14 km) |
| Southampton to Salerno | 1,047.11 mi (1,685.16 km) |
| Southampton to Salo | 658.95 mi (1,060.48 km) |
| Southampton to Salsomaggiore Terme | 673.58 mi (1,084.02 km) |
| Southampton to Saluzzo | 597.10 mi (960.94 km) |
| Southampton to Salzano | 723.00 mi (1,163.56 km) |
| Southampton to Samarate | 593.23 mi (954.71 km) |
| Southampton to San Benedetto del Tronto | 903.84 mi (1,454.59 km) |
| Southampton to San Biagio di Callalta | 727.35 mi (1,170.56 km) |
| Southampton to San Bonifacio | 696.11 mi (1,120.28 km) |
| Southampton to San Casciano in Val di Pesa | 772.04 mi (1,242.47 km) |
| Southampton to San Cataldo | 1,195.33 mi (1,923.70 km) |
| Southampton to San Cesareo | 920.58 mi (1,481.53 km) |
