| Southampton to Santa Venerina | 1,220.41 mi (1,964.05 km) |
| Southampton to Santeramo in Colle | 1,113.70 mi (1,792.33 km) |
| Southampton to Santo Stefano di Magra | 702.66 mi (1,130.82 km) |
| Southampton to Santo Stino di Livenza | 737.56 mi (1,186.98 km) |
| Southampton to Sarezzo | 644.17 mi (1,036.69 km) |
| Southampton to Sarno | 1,035.11 mi (1,665.85 km) |
| Southampton to Saronno | 602.03 mi (968.87 km) |
| Southampton to Sarzana | 706.63 mi (1,137.21 km) |
| Southampton to Sassari | 849.53 mi (1,367.19 km) |
| Southampton to Sasso Marconi | 739.09 mi (1,189.46 km) |
| Southampton to Sassuolo | 715.07 mi (1,150.79 km) |
| Southampton to Sava | 1,162.92 mi (1,871.54 km) |
| Southampton to Saviano | 1,026.49 mi (1,651.97 km) |
| Southampton to Savigliano | 601.42 mi (967.90 km) |
| Southampton to Savignano sul Panaro | 727.30 mi (1,170.47 km) |
