| Southampton to Sestu | 949.09 mi (1,527.41 km) |
| Southampton to Settimo Torinese | 581.04 mi (935.10 km) |
| Southampton to Seveso | 604.89 mi (973.48 km) |
| Southampton to Sezze | 946.05 mi (1,522.53 km) |
| Southampton to Siano | 1,038.58 mi (1,671.43 km) |
| Southampton to Siena | 793.80 mi (1,277.49 km) |
| Southampton to Signa | 762.85 mi (1,227.69 km) |
| Southampton to Silea | 725.25 mi (1,167.18 km) |
| Southampton to Silvi Paese | 931.38 mi (1,498.92 km) |
| Southampton to Sinalunga | 812.97 mi (1,308.35 km) |
| Southampton to Siniscola | 889.99 mi (1,432.30 km) |
| Southampton to Sinnai | 951.79 mi (1,531.75 km) |
| Southampton to Siracusa | 1,259.77 mi (2,027.40 km) |
| Southampton to Solaro | 604.22 mi (972.39 km) |
| Southampton to Soliera | 711.61 mi (1,145.23 km) |
