| Southampton to Spello | 857.63 mi (1,380.22 km) |
| Southampton to Spilamberto | 724.38 mi (1,165.78 km) |
| Southampton to Spilimbergo | 730.82 mi (1,176.14 km) |
| Southampton to Spinea | 726.35 mi (1,168.94 km) |
| Southampton to Spoleto | 869.43 mi (1,399.21 km) |
| Southampton to Spoltore | 936.78 mi (1,507.60 km) |
| Southampton to Spresiano | 718.34 mi (1,156.06 km) |
| Southampton to Squinzano | 1,179.41 mi (1,898.08 km) |
| Southampton to Statte | 1,141.16 mi (1,836.52 km) |
| Southampton to Stezzano | 623.59 mi (1,003.58 km) |
| Southampton to Strada | 780.27 mi (1,255.72 km) |
| Southampton to Stradella | 636.59 mi (1,024.50 km) |
| Southampton to Striano | 1,033.35 mi (1,663.02 km) |
| Southampton to Subiaco | 925.09 mi (1,488.79 km) |
| Southampton to Sulmona | 948.75 mi (1,526.87 km) |
