| Southborough to Sacile | 663.33 mi (1,067.53 km) |
| Southborough to Sala Consilina | 1,044.19 mi (1,680.46 km) |
| Southborough to Salemi | 1,106.43 mi (1,780.62 km) |
| Southborough to Salerno | 1,001.29 mi (1,611.42 km) |
| Southborough to Salo | 606.99 mi (976.86 km) |
| Southborough to Salsomaggiore Terme | 626.71 mi (1,008.59 km) |
| Southborough to Saluzzo | 560.32 mi (901.75 km) |
| Southborough to Salzano | 667.52 mi (1,074.28 km) |
| Southborough to Samarate | 546.54 mi (879.57 km) |
| Southborough to San Benedetto del Tronto | 853.54 mi (1,373.63 km) |
| Southborough to San Biagio di Callalta | 670.72 mi (1,079.42 km) |
| Southborough to San Bonifacio | 643.09 mi (1,034.96 km) |
| Southborough to San Casciano in Val di Pesa | 726.21 mi (1,168.72 km) |
| Southborough to San Cataldo | 1,158.98 mi (1,865.20 km) |
| Southborough to San Cesareo | 876.43 mi (1,410.48 km) |
