| Southport to Sestu | 1,142.79 mi (1,839.14 km) |
| Southport to Settimo Torinese | 760.37 mi (1,223.70 km) |
| Southport to Seveso | 773.21 mi (1,244.35 km) |
| Southport to Sezze | 1,119.83 mi (1,802.19 km) |
| Southport to Siano | 1,208.89 mi (1,945.52 km) |
| Southport to Siena | 966.20 mi (1,554.95 km) |
| Southport to Signa | 933.71 mi (1,502.66 km) |
| Southport to Silea | 876.36 mi (1,410.36 km) |
| Southport to Silvi Paese | 1,095.60 mi (1,763.19 km) |
| Southport to Sinalunga | 984.10 mi (1,583.76 km) |
| Southport to Siniscola | 1,079.31 mi (1,736.97 km) |
| Southport to Sinnai | 1,145.20 mi (1,843.02 km) |
| Southport to Siracusa | 1,440.44 mi (2,318.16 km) |
| Southport to Solaro | 773.05 mi (1,244.11 km) |
| Southport to Soliera | 877.17 mi (1,411.67 km) |
