| Madrid to Santiago de Compostela | 302.22 mi (486.37 km) |
| Madrid to Santiago del Teide | 1,120.21 mi (1,802.81 km) |
| Madrid to Santiponce | 241.35 mi (388.41 km) |
| Madrid to Santomera | 215.97 mi (347.57 km) |
| Madrid to Santona | 209.35 mi (336.92 km) |
| Madrid to Santurce-Antiguo | 204.24 mi (328.69 km) |
| Madrid to Sarria | 252.03 mi (405.61 km) |
| Madrid to Sauzal | 1,096.00 mi (1,763.85 km) |
| Madrid to Sedavi | 188.65 mi (303.61 km) |
| Madrid to Segorbe | 174.18 mi (280.32 km) |
| Madrid to Segovia | 42.66 mi (68.65 km) |
| Madrid to Senmanat | 315.29 mi (507.41 km) |
| Madrid to Sesena | 21.65 mi (34.84 km) |
| Madrid to Sestao | 203.14 mi (326.93 km) |
| Madrid to Sevilla | 251.63 mi (404.96 km) |
