| Spokane to Enterprise (Nevada) | 813.36 mi (1,308.97 km) |
| Spokane to Enumclaw (Washington) | 215.35 mi (346.57 km) |
| Spokane to Ephrata (Pennsylvania) | 2,090.47 mi (3,364.29 km) |
| Spokane to Erie (Colorado) | 810.01 mi (1,303.58 km) |
| Spokane to Erie (Pennsylvania) | 1,849.59 mi (2,976.63 km) |
| Spokane to Erlanger (Kentucky) | 1,740.00 mi (2,800.26 km) |
| Spokane to Escanaba (Michigan) | 1,434.47 mi (2,308.55 km) |
| Spokane to Escondido (California) | 1,004.26 mi (1,616.20 km) |
| Spokane to Española (New Mexico) | 993.51 mi (1,598.90 km) |
| Spokane to Essex (Maryland) | 2,107.52 mi (3,391.72 km) |
| Spokane to Essex Junction (Vermont) | 2,106.26 mi (3,389.70 km) |
| Spokane to Estelle (Louisiana) | 1,901.84 mi (3,060.71 km) |
| Spokane to Estero (Florida) | 2,418.42 mi (3,892.06 km) |
| Spokane to Euclid (Ohio) | 1,797.90 mi (2,893.43 km) |
| Spokane to Eufaula (Alabama) | 2,008.29 mi (3,232.04 km) |
