| Spokane to Scottsbluff (Nebraska) | 783.74 mi (1,261.31 km) |
| Spokane to Scottsboro (Alabama) | 1,846.11 mi (2,971.03 km) |
| Spokane to Scottsdale (Arizona) | 1,008.33 mi (1,622.75 km) |
| Spokane to Scranton (Pennsylvania) | 2,075.73 mi (3,340.57 km) |
| Spokane to Seabrook (Maryland) | 2,099.70 mi (3,379.14 km) |
| Spokane to Seabrook (Texas) | 1,727.13 mi (2,779.55 km) |
| Spokane to Seaford (New York) | 2,199.72 mi (3,540.11 km) |
| Spokane to Seagoville (Texas) | 1,505.01 mi (2,422.08 km) |
| Spokane to Seal Beach (California) | 961.86 mi (1,547.96 km) |
| Spokane to Searcy (Arkansas) | 1,572.12 mi (2,530.08 km) |
| Spokane to Seaside (California) | 795.17 mi (1,279.71 km) |
| Spokane to SeaTac (Washington) | 227.36 mi (365.90 km) |
| Spokane to Seattle (Washington) | 227.68 mi (366.42 km) |
| Spokane to Sebastian (Florida) | 2,407.50 mi (3,874.49 km) |
| Spokane to Sebring (Florida) | 2,380.63 mi (3,831.25 km) |
