| Spokane to Siloam Springs (Arkansas) | 1,411.11 mi (2,270.97 km) |
| Spokane to Silver Firs (Washington) | 219.44 mi (353.16 km) |
| Spokane to Silver Spring (Maryland) | 2,090.99 mi (3,365.12 km) |
| Spokane to Silver Springs Shores (Florida) | 2,276.65 mi (3,663.91 km) |
| Spokane to Silverdale (Washington) | 244.23 mi (393.05 km) |
| Spokane to Silverton (Oregon) | 314.47 mi (506.09 km) |
| Spokane to Simi Valley (California) | 928.41 mi (1,494.13 km) |
| Spokane to Simpsonville (South Carolina) | 2,012.51 mi (3,238.82 km) |
| Spokane to Sioux City (Iowa) | 1,082.94 mi (1,742.82 km) |
| Spokane to Sioux Falls (South Dakota) | 1,037.01 mi (1,668.90 km) |
| Spokane to Skokie (Illinois) | 1,495.42 mi (2,406.64 km) |
| Spokane to Sleepy Hollow (New York) | 2,168.59 mi (3,490.00 km) |
| Spokane to Slidell (Louisiana) | 1,892.06 mi (3,044.97 km) |
| Spokane to Smithfield (North Carolina) | 2,159.09 mi (3,474.72 km) |
| Spokane to Smithfield (Utah) | 487.62 mi (784.75 km) |
