| Spokane to Southchase (Florida) | 2,339.13 mi (3,764.47 km) |
| Spokane to Southern Pines (North Carolina) | 2,123.48 mi (3,417.41 km) |
| Spokane to Southfield (Michigan) | 1,691.03 mi (2,721.46 km) |
| Spokane to Southgate (Michigan) | 1,701.32 mi (2,738.02 km) |
| Spokane to Southlake (Texas) | 1,466.43 mi (2,359.98 km) |
| Spokane to Spanaway (Washington) | 236.71 mi (380.94 km) |
| Spokane to Spanish Fork (Utah) | 596.10 mi (959.33 km) |
| Spokane to Spanish Lake (Missouri) | 1,491.48 mi (2,400.30 km) |
| Spokane to Spanish Springs (Nevada) | 564.57 mi (908.58 km) |
| Spokane to Sparks (Nevada) | 570.68 mi (918.41 km) |
| Spokane to Spartanburg (South Carolina) | 2,018.60 mi (3,248.62 km) |
| Spokane to Spearfish (South Dakota) | 687.47 mi (1,106.38 km) |
| Spokane to Speedway (Indiana) | 1,636.12 mi (2,633.08 km) |
| Spokane to Spencer (Iowa) | 1,120.52 mi (1,803.31 km) |
| Spokane to Spokane Valley (Washington) | 9.24 mi (14.87 km) |
