| Spokane to Superior (Colorado) | 810.75 mi (1,304.77 km) |
| Spokane to Superior (Wisconsin) | 1,187.10 mi (1,910.45 km) |
| Spokane to Surprise (Arizona) | 1,000.39 mi (1,609.98 km) |
| Spokane to Susanville (California) | 524.88 mi (844.72 km) |
| Spokane to Sussex (Wisconsin) | 1,442.12 mi (2,320.87 km) |
| Spokane to Suwanee (Georgia) | 1,959.87 mi (3,154.10 km) |
| Spokane to Swansea (Illinois) | 1,510.50 mi (2,430.92 km) |
| Spokane to Sweetwater (Florida) | 2,511.38 mi (4,041.67 km) |
| Spokane to Sweetwater (Texas) | 1,376.78 mi (2,215.72 km) |
| Spokane to Sycamore (Illinois) | 1,452.91 mi (2,338.24 km) |
| Spokane to Sylacauga (Alabama) | 1,901.77 mi (3,060.61 km) |
| Spokane to Sylvania (Ohio) | 1,692.40 mi (2,723.66 km) |
| Spokane to Syosset (New York) | 2,194.55 mi (3,531.78 km) |
| Spokane to Syracuse (New York) | 2,005.69 mi (3,227.85 km) |
| Spokane to Syracuse (Utah) | 525.92 mi (846.39 km) |
