| Spoleto to Sacile | 221.99 mi (357.26 km) |
| Spoleto to Sala Consilina | 221.78 mi (356.93 km) |
| Spoleto to Salemi | 341.36 mi (549.37 km) |
| Spoleto to Salerno | 178.92 mi (287.94 km) |
| Spoleto to Salo | 223.52 mi (359.73 km) |
| Spoleto to Salsomaggiore Terme | 196.04 mi (315.50 km) |
| Spoleto to Saluzzo | 290.38 mi (467.33 km) |
| Spoleto to Salzano | 193.92 mi (312.08 km) |
| Spoleto to Samarate | 276.40 mi (444.82 km) |
| Spoleto to San Benedetto del Tronto | 62.13 mi (99.98 km) |
| Spoleto to San Biagio di Callalta | 203.02 mi (326.72 km) |
| Spoleto to San Bonifacio | 195.45 mi (314.55 km) |
| Spoleto to San Casciano in Val di Pesa | 97.85 mi (157.47 km) |
| Spoleto to San Cataldo | 370.73 mi (596.62 km) |
| Spoleto to San Cesareo | 65.20 mi (104.92 km) |
