| Spoleto to Santa Venerina | 373.51 mi (601.10 km) |
| Spoleto to Santeramo in Colle | 249.94 mi (402.24 km) |
| Spoleto to Santo Stefano di Magra | 169.52 mi (272.81 km) |
| Spoleto to Santo Stino di Livenza | 205.68 mi (331.01 km) |
| Spoleto to Sarezzo | 234.76 mi (377.81 km) |
| Spoleto to Sarno | 166.91 mi (268.61 km) |
| Spoleto to Saronno | 268.21 mi (431.63 km) |
| Spoleto to Sarzana | 165.79 mi (266.81 km) |
| Spoleto to Sassari | 254.75 mi (409.98 km) |
| Spoleto to Sasso Marconi | 134.37 mi (216.25 km) |
| Spoleto to Sassuolo | 156.21 mi (251.40 km) |
| Spoleto to Sava | 300.17 mi (483.08 km) |
| Spoleto to Saviano | 158.25 mi (254.67 km) |
| Spoleto to Savigliano | 284.18 mi (457.34 km) |
| Spoleto to Savignano sul Panaro | 145.13 mi (233.56 km) |
