| Spoleto to Selargius | 303.83 mi (488.97 km) |
| Spoleto to Selvazzano Dentro | 186.94 mi (300.84 km) |
| Spoleto to Senago | 262.89 mi (423.08 km) |
| Spoleto to Senigallia | 71.33 mi (114.79 km) |
| Spoleto to Seravezza | 150.15 mi (241.64 km) |
| Spoleto to Seregno | 264.09 mi (425.01 km) |
| Spoleto to Seriate | 250.01 mi (402.36 km) |
| Spoleto to Sermoneta | 84.75 mi (136.38 km) |
| Spoleto to Serramanna | 302.37 mi (486.62 km) |
| Spoleto to Serravalle Pistoiese | 122.10 mi (196.49 km) |
| Spoleto to Sessa Aurunca | 123.21 mi (198.29 km) |
| Spoleto to Sesto Calende | 287.21 mi (462.21 km) |
| Spoleto to Sesto Fiorentino | 105.43 mi (169.67 km) |
| Spoleto to Sesto San Giovanni | 257.06 mi (413.70 km) |
| Spoleto to Sestri Levante | 195.42 mi (314.49 km) |
