| Spoleto to Solofra | 173.45 mi (279.14 km) |
| Spoleto to Somma Lombardo | 282.49 mi (454.62 km) |
| Spoleto to Somma Vesuviana | 158.35 mi (254.85 km) |
| Spoleto to Sommacampagna | 204.10 mi (328.46 km) |
| Spoleto to Sona | 206.51 mi (332.35 km) |
| Spoleto to Sondrio | 273.62 mi (440.35 km) |
| Spoleto to Sora | 86.20 mi (138.72 km) |
| Spoleto to Sorbolo | 182.44 mi (293.62 km) |
| Spoleto to Soresina | 224.26 mi (360.91 km) |
| Spoleto to Sorisole | 254.71 mi (409.92 km) |
| Spoleto to Sorrento | 170.92 mi (275.07 km) |
| Spoleto to Sorso | 251.18 mi (404.24 km) |
| Spoleto to Sortino | 405.69 mi (652.90 km) |
| Spoleto to Soverato Marina | 346.55 mi (557.71 km) |
| Spoleto to Sovicille | 81.89 mi (131.79 km) |
