| Spoleto to Santander | 831.87 mi (1,338.77 km) |
| Spoleto to Santany | 550.20 mi (885.47 km) |
| Spoleto to Santiago de Compostela | 1,073.14 mi (1,727.05 km) |
| Spoleto to Santiago del Teide | 1,921.46 mi (3,092.30 km) |
| Spoleto to Santiponce | 1,053.20 mi (1,694.96 km) |
| Spoleto to Santomera | 790.80 mi (1,272.67 km) |
| Spoleto to Santona | 814.51 mi (1,310.83 km) |
| Spoleto to Santurce-Antiguo | 793.46 mi (1,276.94 km) |
| Spoleto to Sarria | 1,017.17 mi (1,636.98 km) |
| Spoleto to Sauzal | 1,895.57 mi (3,050.63 km) |
| Spoleto to Sedavi | 717.53 mi (1,154.76 km) |
| Spoleto to Segorbe | 711.82 mi (1,145.56 km) |
| Spoleto to Segovia | 872.30 mi (1,403.83 km) |
| Spoleto to Senmanat | 545.55 mi (877.98 km) |
| Spoleto to Sesena | 866.81 mi (1,394.99 km) |
