| Spoleto to Sestao | 792.22 mi (1,274.96 km) |
| Spoleto to Sevilla | 1,056.62 mi (1,700.47 km) |
| Spoleto to Sevilla La Nueva | 878.57 mi (1,413.92 km) |
| Spoleto to Silla | 720.55 mi (1,159.61 km) |
| Spoleto to Silleda | 1,059.00 mi (1,704.29 km) |
| Spoleto to Sitges | 568.15 mi (914.35 km) |
| Spoleto to Socuellamos | 840.22 mi (1,352.20 km) |
| Spoleto to Soller | 557.81 mi (897.70 km) |
| Spoleto to Solsona | 572.03 mi (920.59 km) |
| Spoleto to Son Servera | 530.69 mi (854.07 km) |
| Spoleto to Sonseca | 888.26 mi (1,429.52 km) |
| Spoleto to Sopelana | 790.69 mi (1,272.49 km) |
| Spoleto to Soria | 776.76 mi (1,250.08 km) |
| Spoleto to Suances | 844.24 mi (1,358.67 km) |
| Spoleto to Sueca | 720.11 mi (1,158.90 km) |
