| Spoleto to Emeryville (California) | 6,192.37 mi (9,965.66 km) |
| Spoleto to Emmaus (Pennsylvania) | 4,331.00 mi (6,970.07 km) |
| Spoleto to Emporia (Kansas) | 5,277.14 mi (8,492.73 km) |
| Spoleto to Encinitas (California) | 6,317.08 mi (10,166.36 km) |
| Spoleto to Endicott (New York) | 4,294.79 mi (6,911.80 km) |
| Spoleto to Endwell (New York) | 4,292.22 mi (6,907.66 km) |
| Spoleto to Englewood (Colorado) | 5,539.97 mi (8,915.72 km) |
| Spoleto to Englewood (Florida) | 5,216.28 mi (8,394.80 km) |
| Spoleto to Englewood (New Jersey) | 4,251.01 mi (6,841.34 km) |
| Spoleto to Englewood (Ohio) | 4,732.75 mi (7,616.62 km) |
| Spoleto to Enid (Oklahoma) | 5,439.71 mi (8,754.36 km) |
| Spoleto to Ennis (Texas) | 5,591.32 mi (8,998.36 km) |
| Spoleto to Ensley (Florida) | 5,277.50 mi (8,493.32 km) |
| Spoleto to Enterprise (Alabama) | 5,177.48 mi (8,332.35 km) |
| Spoleto to Enterprise (Nevada) | 6,083.13 mi (9,789.85 km) |
