| Spoleto to Enumclaw (Washington) | 5,632.78 mi (9,065.09 km) |
| Spoleto to Ephrata (Pennsylvania) | 4,374.51 mi (7,040.09 km) |
| Spoleto to Erie (Colorado) | 5,521.14 mi (8,885.41 km) |
| Spoleto to Erie (Pennsylvania) | 4,462.82 mi (7,182.21 km) |
| Spoleto to Erlanger (Kentucky) | 4,781.20 mi (7,694.60 km) |
| Spoleto to Escanaba (Michigan) | 4,592.44 mi (7,390.83 km) |
| Spoleto to Escondido (California) | 6,306.04 mi (10,148.59 km) |
| Spoleto to Española (New Mexico) | 5,768.73 mi (9,283.88 km) |
| Spoleto to Essex (Maryland) | 4,420.81 mi (7,114.61 km) |
| Spoleto to Essex Junction (Vermont) | 4,080.75 mi (6,567.33 km) |
| Spoleto to Estelle (Louisiana) | 5,433.85 mi (8,744.94 km) |
| Spoleto to Estero (Florida) | 5,214.90 mi (8,392.57 km) |
| Spoleto to Euclid (Ohio) | 4,544.34 mi (7,313.41 km) |
| Spoleto to Eufaula (Alabama) | 5,120.17 mi (8,240.11 km) |
| Spoleto to Eugene (Oregon) | 5,846.67 mi (9,409.30 km) |
