| Spring to Enterprise (Nevada) | 1,218.00 mi (1,960.19 km) |
| Spring to Enumclaw (Washington) | 1,845.30 mi (2,969.72 km) |
| Spring to Ephrata (Pennsylvania) | 1,286.54 mi (2,070.49 km) |
| Spring to Erie (Colorado) | 878.43 mi (1,413.70 km) |
| Spring to Erie (Pennsylvania) | 1,189.95 mi (1,915.03 km) |
| Spring to Erlanger (Kentucky) | 870.50 mi (1,400.93 km) |
| Spring to Escanaba (Michigan) | 1,172.74 mi (1,887.35 km) |
| Spring to Escondido (California) | 1,291.55 mi (2,078.55 km) |
| Spring to Española (New Mexico) | 742.04 mi (1,194.19 km) |
| Spring to Essex (Maryland) | 1,247.35 mi (2,007.42 km) |
| Spring to Essex Junction (Vermont) | 1,569.75 mi (2,526.27 km) |
| Spring to Estelle (Louisiana) | 316.47 mi (509.30 km) |
| Spring to Estero (Florida) | 863.65 mi (1,389.92 km) |
| Spring to Euclid (Ohio) | 1,109.74 mi (1,785.96 km) |
| Spring to Eufaula (Alabama) | 619.16 mi (996.44 km) |
