| Street to Savignano sul Rubicone | 853.65 mi (1,373.81 km) |
| Street to Savona | 701.28 mi (1,128.60 km) |
| Street to Scafati | 1,091.25 mi (1,756.20 km) |
| Street to Scalea | 1,184.40 mi (1,906.11 km) |
| Street to Scandiano | 766.88 mi (1,234.17 km) |
| Street to Scandicci | 824.06 mi (1,326.20 km) |
| Street to Schio | 744.90 mi (1,198.80 km) |
| Street to Sciacca | 1,218.18 mi (1,960.47 km) |
| Street to Scicli | 1,309.71 mi (2,107.77 km) |
| Street to Scordia | 1,286.02 mi (2,069.65 km) |
| Street to Scorze | 780.23 mi (1,255.65 km) |
| Street to Sedico | 759.01 mi (1,221.51 km) |
| Street to Sedriano | 663.01 mi (1,067.01 km) |
| Street to Segni | 990.72 mi (1,594.41 km) |
| Street to Segrate | 674.93 mi (1,086.19 km) |
