| Street to Sestu | 996.82 mi (1,604.22 km) |
| Street to Settimo Torinese | 636.09 mi (1,023.70 km) |
| Street to Seveso | 662.30 mi (1,065.87 km) |
| Street to Sezze | 1,001.71 mi (1,612.10 km) |
| Street to Siano | 1,094.87 mi (1,762.02 km) |
| Street to Siena | 850.01 mi (1,367.96 km) |
| Street to Signa | 819.44 mi (1,318.76 km) |
| Street to Silea | 784.47 mi (1,262.48 km) |
| Street to Silvi Paese | 988.88 mi (1,591.45 km) |
| Street to Sinalunga | 869.41 mi (1,399.19 km) |
| Street to Siniscola | 940.44 mi (1,513.49 km) |
| Street to Sinnai | 999.71 mi (1,608.88 km) |
| Street to Siracusa | 1,313.17 mi (2,113.34 km) |
| Street to Solaro | 661.54 mi (1,064.65 km) |
| Street to Soliera | 769.23 mi (1,237.96 km) |
