| Upton to Spello | 1,017.36 mi (1,637.28 km) |
| Upton to Spilamberto | 882.55 mi (1,420.33 km) |
| Upton to Spilimbergo | 868.90 mi (1,398.37 km) |
| Upton to Spinea | 872.91 mi (1,404.81 km) |
| Upton to Spoleto | 1,030.20 mi (1,657.94 km) |
| Upton to Spoltore | 1,093.52 mi (1,759.84 km) |
| Upton to Spresiano | 862.21 mi (1,387.59 km) |
| Upton to Squinzano | 1,331.34 mi (2,142.58 km) |
| Upton to Statte | 1,295.38 mi (2,084.71 km) |
| Upton to Stezzano | 780.65 mi (1,256.34 km) |
| Upton to Strada | 942.38 mi (1,516.61 km) |
| Upton to Stradella | 799.04 mi (1,285.93 km) |
| Upton to Striano | 1,195.44 mi (1,923.87 km) |
| Upton to Subiaco | 1,087.90 mi (1,750.81 km) |
| Upton to Sulmona | 1,108.13 mi (1,783.36 km) |
