| Valletta to Sacile | 703.48 mi (1,132.14 km) |
| Valletta to Sala Consilina | 316.59 mi (509.51 km) |
| Valletta to Salemi | 162.88 mi (262.13 km) |
| Valletta to Salerno | 330.70 mi (532.20 km) |
| Valletta to Salo | 701.69 mi (1,129.26 km) |
| Valletta to Salsomaggiore Terme | 660.40 mi (1,062.81 km) |
| Valletta to Saluzzo | 708.07 mi (1,139.53 km) |
| Valletta to Salzano | 677.35 mi (1,090.08 km) |
| Valletta to Samarate | 734.89 mi (1,182.69 km) |
| Valletta to San Benedetto del Tronto | 488.38 mi (785.97 km) |
| Valletta to San Biagio di Callalta | 685.37 mi (1,102.99 km) |
| Valletta to San Bonifacio | 677.82 mi (1,090.84 km) |
| Valletta to San Casciano in Val di Pesa | 564.29 mi (908.14 km) |
| Valletta to San Cataldo | 113.37 mi (182.45 km) |
| Valletta to San Cesareo | 419.15 mi (674.55 km) |
