| Valletta to Santa Venerina | 128.02 mi (206.04 km) |
| Valletta to Santeramo in Colle | 359.99 mi (579.35 km) |
| Valletta to Santo Stefano di Magra | 620.38 mi (998.40 km) |
| Valletta to Santo Stino di Livenza | 686.18 mi (1,104.30 km) |
| Valletta to Sarezzo | 710.27 mi (1,143.07 km) |
| Valletta to Sarno | 339.88 mi (546.98 km) |
| Valletta to Saronno | 730.17 mi (1,175.09 km) |
| Valletta to Sarzana | 616.38 mi (991.97 km) |
| Valletta to Sassari | 463.95 mi (746.65 km) |
| Valletta to Sasso Marconi | 612.02 mi (984.95 km) |
| Valletta to Sassuolo | 629.20 mi (1,012.60 km) |
| Valletta to Sava | 352.50 mi (567.29 km) |
| Valletta to Saviano | 346.74 mi (558.02 km) |
| Valletta to Savigliano | 704.47 mi (1,133.73 km) |
| Valletta to Savignano sul Panaro | 620.78 mi (999.04 km) |
