| Valletta to Sangeorz-Bai | 948.94 mi (1,527.18 km) |
| Valletta to Sannicolau Mare | 770.47 mi (1,239.96 km) |
| Valletta to Santana | 807.76 mi (1,299.96 km) |
| Valletta to Satu Mare | 926.61 mi (1,491.23 km) |
| Valletta to Scobinti | 1,017.67 mi (1,637.79 km) |
| Valletta to Scornicesti | 798.32 mi (1,284.77 km) |
| Valletta to Sebes | 839.51 mi (1,351.06 km) |
| Valletta to Seini | 933.64 mi (1,502.55 km) |
| Valletta to Sfantu-Gheorghe | 904.25 mi (1,455.26 km) |
| Valletta to Sibiu | 847.88 mi (1,364.53 km) |
| Valletta to Sighetu Marmatiei | 959.35 mi (1,543.92 km) |
| Valletta to Sighisoara | 890.05 mi (1,432.40 km) |
| Valletta to Simeria | 817.38 mi (1,315.45 km) |
| Valletta to Sinaia | 871.04 mi (1,401.81 km) |
| Valletta to Slatina | 784.99 mi (1,263.32 km) |
