| Valletta to Santander | 1,101.99 mi (1,773.48 km) |
| Valletta to Santany | 666.56 mi (1,072.73 km) |
| Valletta to Santiago de Compostela | 1,317.01 mi (2,119.53 km) |
| Valletta to Santiago del Teide | 1,898.23 mi (3,054.90 km) |
| Valletta to Santiponce | 1,141.89 mi (1,837.69 km) |
| Valletta to Santomera | 870.75 mi (1,401.34 km) |
| Valletta to Santona | 1,085.31 mi (1,746.64 km) |
| Valletta to Santurce-Antiguo | 1,062.61 mi (1,710.10 km) |
| Valletta to Sarria | 1,260.02 mi (2,027.81 km) |
| Valletta to Sauzal | 1,872.02 mi (3,012.72 km) |
| Valletta to Sedavi | 849.35 mi (1,366.90 km) |
| Valletta to Segorbe | 861.32 mi (1,386.16 km) |
| Valletta to Segovia | 1,064.62 mi (1,713.34 km) |
| Valletta to Senmanat | 773.72 mi (1,245.18 km) |
| Valletta to Sesena | 1,031.05 mi (1,659.32 km) |
