| Head north on Strada Statale 145var Galleria Santa Maria di Pozzano (SS145var) | 4 km |
| Continue onto Strada Statale Sorrentina Panoramica (SS145) | 1 km |
| Continue onto Strada Statale 145 Sorrentina (SS145) | 150 m |
| Continue onto Galleria Privati (SS145) | 2 km |
| Continue onto Strada Statale 145 Sorrentina (SS145) | 6 km |
| Go straight | 350 m |
| Go straight | 150 m |
| Keep right towards Salerno | 400 m |
| Merge left onto Autostrada A3 Napoli-Salerno (A3) | 30 km |
| Continue onto Diramazione Napoli (A2dirNA) | 3.5 km |
| Continue onto Autostrada del Mediterraneo (A2) | 250 km |
| Continue onto Acqua di Calci (A2) | 350 m |
| Continue onto Autostrada Viadotto Molino Irto (A2) | 600 m |
| Continue onto Viadotto Torre Trocini (A2) | 550 m |
| Continue onto Viadotto Specola (A2) | 400 m |
| Continue onto Viadotto San Martino (A2) | 600 m |
| Continue onto Autostrada del Mediterraneo (A2) | 300 m |
| Continue onto Viadotto Profenna (A2) | 900 m |
| Continue onto Autostrada del Mediterraneo (A2) | 150 km |
| Take the ramp | 1 km |
| Enter the traffic circle and take the 4th exit | 100 m |
| Exit the traffic circle | 350 m |
| Keep right towards A2: Salerno | 450 m |
| Merge left onto Diramazione Reggio Calabria (A2dirRC) | 250 m |
| Take the ramp | 700 m |
| Continue onto Strada Statale 738 di Villa San Giovanni (SS738) | 1.5 km |
| Turn left onto Viale Italia | 200 m |
| Turn left | 90 m |
| Continue onto Via dei Marinai d'Italia | 250 m |
| Make a slight left | 100 m |
| Keep straight at the fork | 200 m |
| Turn left | 200 m |
| Make a sharp right | 20 m |
| Take the ferry Messina - Villa San Giovanni | 7 km |
| Continue slight left | 700 m |
| Turn left | 35 m |
| Go straight onto Viale della Libertà | 900 m |
| Make a slight right onto Corso Cavour | 200 m |
| Turn right onto Viale Boccetta | 900 m |
| Take the ramp towards A20: autostrade | 150 m |
| Continue towards A20 | 200 m |
| Continue straight | 350 m |
| Keep right towards Catania | 400 m |
| Merge left onto Autostrada Messina-Palermo (A20) | 900 m |
| Continue onto Galleria Spadalara (A20) | 450 m |
| Continue onto Viadotto Camaro (A20) | 350 m |
| Keep left onto Autostrada Messina-Palermo (A20) | 350 m |
| Continue onto Galleria Perara (A20) | 450 m |
| Continue onto Viadotto Calorende (A20) | 250 m |
| Continue onto Galleria Bordonaro (A20) | 250 m |
| Continue onto Viadotto Bordonaro (A20) | 550 m |
| Continue onto Autostrada Messina-Palermo (A20) | 5.5 km |
| Continue onto Autostrada Messina-Catania (A18) | 700 m |
| Take the ramp on the left | 150 m |
| Merge right onto Autostrada Messina-Catania (A18) | 4.5 km |
| Continue onto Galleria Serra (A18) | 350 m |
| Continue onto Autostrada Messina-Catania (A18) | 3.5 km |
| Continue onto Galleria Piano Cutiri (A18) | 1.5 km |
| Continue onto Viadotto Racinazzi (A18) | 200 m |
| Continue onto Galleria Scaletta Zanclea (A18) | 600 m |
| Continue onto Autostrada Messina-Catania (A18) | 70 km |
| Take the ramp on the left | 200 m |
| Merge right onto Autostrada Messina-Catania (A18) | 400 m |
| Keep left towards tangenziale | 80 m |
| Continue onto Tangenziale Ovest di Catania (RA15) | 3 km |
| Continue onto Viadotto San Paolo (RA15) | 400 m |
| Continue onto Tangenziale Ovest di Catania (RA15) | 15 km |
| Keep left towards Lentini-Carlentini | 25 km |
| Continue onto Strada statale Orientale Sicula (SS114) | 20 km |
| Continue onto Strada statale Orientale Sicula (SS114) | 2 km |
| Continue onto Autostrada Siracusa-Gela (A18) | 45 km |
| Take the ramp | 1 km |
| Keep left at the fork | 700 m |
| Keep left at the fork | 80 m |
| Enter the traffic circle and take the 3rd exit | 90 m |
| Exit the traffic circle | 60 m |
| Continue onto Strada provinciale Ispica-Pozzallo (SP46) | 1 km |
| Continue onto Via Giuseppe Renda (SP46) | 2.5 km |
| Continue onto Via Mario Rapisardi | 150 m |
| Enter the traffic circle and take the 2nd exit onto Via Mario Rapisardi | 20 m |
| Exit the traffic circle onto Via Mario Rapisardi | 250 m |
| Enter the traffic circle and take the 1st exit | 10 m |
| Exit the traffic circle | 70 m |
| Enter the traffic circle and take the 1st exit | 3.5 m |
| Exit the traffic circle | 70 m |
| Continue onto Viale Europa | 300 m |
| Keep left at the fork | 10 m |
| Keep left at the fork | 20 m |
| Keep right onto Viale Papa Giovanni Ventitreesimo | 400 m |
| Enter the traffic circle and take the 1st exit | 3 m |
| Exit the traffic circle | 100 m |
| Continue onto Via Torino | 150 m |
| Turn left onto Via Roma | 900 m |
| Turn right | 25 m |
| Turn left onto Largo dei Vespri Siciliani | 500 m |
| Continue onto Viale Medaglie d'Oro Lunga Navigazione | 800 m |
| Make a slight left | 90 m |
| Turn left | 20 m |
| Turn right | 300 m |
| Take the ferry Malta - Pozzallo | 100 km |
| Continue straight | 70 m |
| Turn left | 35 m |
| Turn left onto Xatt l-Għassara tal-Għeneb | 90 m |
| Continue onto Triq Moll iċ-Ċangatura | 250 m |
| Enter the traffic circle and take the 3rd exit | 60 m |
| Exit the traffic circle | 25 m |
| Continue onto It-Telgħa ta Spencer | 250 m |
| Enter the traffic circle and take the 1st exit | 10 m |
| Exit the traffic circle | 25 m |
| Continue onto It-Telgħa ta' Spencer | 100 m |
| Turn left onto Triq Nazzjonali (6) | 200 m |
| Take the ramp onto Triq Nazzjonali (6) | 55 m |
| Keep left onto Triq Nazzjonali (6) | 150 m |
| Go straight onto Triq il-Kbira San Ġużepp (130) | 1.5 km |
| Turn right onto Triq it-Turretta | 50 m |
| You have arrived at your destination, straight ahead | 0 m |
