| Vila Nova de Gaia to Sacile | 1,105.10 mi (1,778.49 km) |
| Vila Nova de Gaia to Sala Consilina | 1,264.18 mi (2,034.50 km) |
| Vila Nova de Gaia to Salemi | 1,161.85 mi (1,869.82 km) |
| Vila Nova de Gaia to Salerno | 1,217.42 mi (1,959.25 km) |
| Vila Nova de Gaia to Salo | 1,007.31 mi (1,621.11 km) |
| Vila Nova de Gaia to Salsomaggiore Terme | 971.48 mi (1,563.45 km) |
| Vila Nova de Gaia to Saluzzo | 849.10 mi (1,366.49 km) |
| Vila Nova de Gaia to Salzano | 1,081.94 mi (1,741.22 km) |
| Vila Nova de Gaia to Samarate | 924.87 mi (1,488.44 km) |
| Vila Nova de Gaia to San Benedetto del Tronto | 1,157.84 mi (1,863.36 km) |
| Vila Nova de Gaia to San Biagio di Callalta | 1,096.25 mi (1,764.25 km) |
| Vila Nova de Gaia to San Bonifacio | 1,040.61 mi (1,674.70 km) |
| Vila Nova de Gaia to San Casciano in Val di Pesa | 1,022.83 mi (1,646.09 km) |
| Vila Nova de Gaia to San Cataldo | 1,230.55 mi (1,980.37 km) |
| Vila Nova de Gaia to San Cesareo | 1,106.83 mi (1,781.27 km) |
