| Vila Real de Santo Antonio to Sestu | 906.16 mi (1,458.33 km) |
| Vila Real de Santo Antonio to Settimo Torinese | 959.02 mi (1,543.39 km) |
| Vila Real de Santo Antonio to Seveso | 1,034.27 mi (1,664.50 km) |
| Vila Real de Santo Antonio to Sezze | 1,131.10 mi (1,820.33 km) |
| Vila Real de Santo Antonio to Siano | 1,209.70 mi (1,946.82 km) |
| Vila Real de Santo Antonio to Siena | 1,072.22 mi (1,725.58 km) |
| Vila Real de Santo Antonio to Signa | 1,071.04 mi (1,723.67 km) |
| Vila Real de Santo Antonio to Silea | 1,172.12 mi (1,886.35 km) |
| Vila Real de Santo Antonio to Silvi Paese | 1,196.42 mi (1,925.45 km) |
| Vila Real de Santo Antonio to Sinalunga | 1,089.63 mi (1,753.60 km) |
| Vila Real de Santo Antonio to Siniscola | 947.83 mi (1,525.38 km) |
| Vila Real de Santo Antonio to Sinnai | 912.11 mi (1,467.91 km) |
| Vila Real de Santo Antonio to Siracusa | 1,247.63 mi (2,007.86 km) |
| Vila Real de Santo Antonio to Solaro | 1,031.07 mi (1,659.34 km) |
| Vila Real de Santo Antonio to Soliera | 1,086.09 mi (1,747.89 km) |
