| Vila Real de Santo Antonio to Spello | 1,131.34 mi (1,820.71 km) |
| Vila Real de Santo Antonio to Spilamberto | 1,085.02 mi (1,746.17 km) |
| Vila Real de Santo Antonio to Spilimbergo | 1,211.01 mi (1,948.93 km) |
| Vila Real de Santo Antonio to Spinea | 1,161.73 mi (1,869.62 km) |
| Vila Real de Santo Antonio to Spoleto | 1,128.23 mi (1,815.71 km) |
| Vila Real de Santo Antonio to Spoltore | 1,196.37 mi (1,925.37 km) |
| Vila Real de Santo Antonio to Spresiano | 1,173.55 mi (1,888.65 km) |
| Vila Real de Santo Antonio to Squinzano | 1,384.19 mi (2,227.64 km) |
| Vila Real de Santo Antonio to Statte | 1,339.80 mi (2,156.19 km) |
| Vila Real de Santo Antonio to Stezzano | 1,056.49 mi (1,700.25 km) |
| Vila Real de Santo Antonio to Strada | 1,076.98 mi (1,733.23 km) |
| Vila Real de Santo Antonio to Stradella | 1,023.45 mi (1,647.09 km) |
| Vila Real de Santo Antonio to Striano | 1,203.12 mi (1,936.24 km) |
| Vila Real de Santo Antonio to Subiaco | 1,137.59 mi (1,830.78 km) |
| Vila Real de Santo Antonio to Sulmona | 1,180.75 mi (1,900.23 km) |
