| Webster Groves to Southchase (Florida) | 873.18 mi (1,405.24 km) |
| Webster Groves to Southern Pines (North Carolina) | 648.44 mi (1,043.57 km) |
| Webster Groves to Southfield (Michigan) | 459.10 mi (738.84 km) |
| Webster Groves to Southgate (Michigan) | 451.41 mi (726.47 km) |
| Webster Groves to Southlake (Texas) | 544.26 mi (875.90 km) |
| Webster Groves to Spanaway (Washington) | 1,713.39 mi (2,757.43 km) |
| Webster Groves to Spanish Fork (Utah) | 1,139.44 mi (1,833.76 km) |
| Webster Groves to Spanish Lake (Missouri) | 16.03 mi (25.80 km) |
| Webster Groves to Spanish Springs (Nevada) | 1,566.13 mi (2,520.44 km) |
| Webster Groves to Sparks (Nevada) | 1,569.28 mi (2,525.52 km) |
| Webster Groves to Spartanburg (South Carolina) | 529.79 mi (852.62 km) |
| Webster Groves to Spearfish (South Dakota) | 805.39 mi (1,296.14 km) |
| Webster Groves to Speedway (Indiana) | 235.15 mi (378.44 km) |
| Webster Groves to Spencer (Iowa) | 402.53 mi (647.80 km) |
| Webster Groves to Spokane (Washington) | 1,492.54 mi (2,402.01 km) |
