| Winston-Salem to Sestu | 4,674.14 mi (7,522.30 km) |
| Winston-Salem to Settimo Torinese | 4,426.96 mi (7,124.50 km) |
| Winston-Salem to Seveso | 4,470.87 mi (7,195.16 km) |
| Winston-Salem to Sezze | 4,780.38 mi (7,693.27 km) |
| Winston-Salem to Siano | 4,877.79 mi (7,850.04 km) |
| Winston-Salem to Siena | 4,641.37 mi (7,469.56 km) |
| Winston-Salem to Signa | 4,615.79 mi (7,428.40 km) |
| Winston-Salem to Silea | 4,605.77 mi (7,412.26 km) |
| Winston-Salem to Silvi Paese | 4,790.05 mi (7,708.85 km) |
| Winston-Salem to Sinalunga | 4,662.46 mi (7,503.51 km) |
| Winston-Salem to Siniscola | 4,659.37 mi (7,498.53 km) |
| Winston-Salem to Sinnai | 4,679.23 mi (7,530.49 km) |
| Winston-Salem to Siracusa | 5,041.84 mi (8,114.06 km) |
| Winston-Salem to Solaro | 4,469.44 mi (7,192.86 km) |
| Winston-Salem to Soliera | 4,576.89 mi (7,365.80 km) |
