| Winston-Salem to Des Plaines (Illinois) | 579.12 mi (932.00 km) |
| Winston-Salem to Desert Hot Springs (California) | 2,046.25 mi (3,293.12 km) |
| Winston-Salem to DeSoto (Texas) | 976.13 mi (1,570.92 km) |
| Winston-Salem to Destin (Florida) | 532.89 mi (857.61 km) |
| Winston-Salem to Destrehan (Louisiana) | 722.29 mi (1,162.41 km) |
| Winston-Salem to Detroit (Michigan) | 459.73 mi (739.86 km) |
| Winston-Salem to Diamond Bar (California) | 2,116.02 mi (3,405.41 km) |
| Winston-Salem to Diamond Springs (California) | 2,216.37 mi (3,566.91 km) |
| Winston-Salem to Dickinson (North Dakota) | 1,376.24 mi (2,214.84 km) |
| Winston-Salem to Dickinson (Texas) | 973.08 mi (1,566.02 km) |
| Winston-Salem to Dickson (Tennessee) | 396.68 mi (638.40 km) |
| Winston-Salem to Difficult Run (Virginia) | 250.77 mi (403.58 km) |
| Winston-Salem to Dinuba (California) | 2,163.59 mi (3,481.96 km) |
| Winston-Salem to Discovery Bay (California) | 2,265.59 mi (3,646.12 km) |
| Winston-Salem to Dix Hills (New York) | 495.50 mi (797.43 km) |
