| Winston-Salem to Elyria (Ohio) | 377.63 mi (607.74 km) |
| Winston-Salem to Emeryville (California) | 2,303.70 mi (3,707.44 km) |
| Winston-Salem to Emmaus (Pennsylvania) | 400.43 mi (644.43 km) |
| Winston-Salem to Emporia (Kansas) | 889.32 mi (1,431.23 km) |
| Winston-Salem to Encinitas (California) | 2,102.82 mi (3,384.16 km) |
| Winston-Salem to Endicott (New York) | 471.25 mi (758.41 km) |
| Winston-Salem to Endwell (New York) | 473.55 mi (762.10 km) |
| Winston-Salem to Englewood (Colorado) | 1,366.44 mi (2,199.08 km) |
| Winston-Salem to Englewood (Florida) | 642.76 mi (1,034.42 km) |
| Winston-Salem to Englewood (New Jersey) | 474.16 mi (763.09 km) |
| Winston-Salem to Englewood (Ohio) | 340.64 mi (548.20 km) |
| Winston-Salem to Enid (Oklahoma) | 979.98 mi (1,577.12 km) |
| Winston-Salem to Ennis (Texas) | 969.89 mi (1,560.89 km) |
| Winston-Salem to Ensley (Florida) | 558.62 mi (899.01 km) |
| Winston-Salem to Enterprise (Alabama) | 460.15 mi (740.55 km) |
