| Winston-Salem to Enterprise (Nevada) | 1,942.44 mi (3,126.06 km) |
| Winston-Salem to Enumclaw (Washington) | 2,255.53 mi (3,629.92 km) |
| Winston-Salem to Ephrata (Pennsylvania) | 358.44 mi (576.86 km) |
| Winston-Salem to Erie (Colorado) | 1,370.28 mi (2,205.26 km) |
| Winston-Salem to Erie (Pennsylvania) | 415.63 mi (668.90 km) |
| Winston-Salem to Erlanger (Kentucky) | 310.58 mi (499.82 km) |
| Winston-Salem to Escanaba (Michigan) | 755.07 mi (1,215.17 km) |
| Winston-Salem to Escondido (California) | 2,090.68 mi (3,364.62 km) |
| Winston-Salem to Española (New Mexico) | 1,437.34 mi (2,313.18 km) |
| Winston-Salem to Essex (Maryland) | 303.88 mi (489.04 km) |
| Winston-Salem to Essex Junction (Vermont) | 690.51 mi (1,111.26 km) |
| Winston-Salem to Estelle (Louisiana) | 715.11 mi (1,150.86 km) |
| Winston-Salem to Estero (Florida) | 674.58 mi (1,085.63 km) |
| Winston-Salem to Euclid (Ohio) | 385.12 mi (619.80 km) |
| Winston-Salem to Eufaula (Alabama) | 402.80 mi (648.25 km) |
