| Winston-Salem to Indianapolis (Indiana) | 408.83 mi (657.94 km) |
| Winston-Salem to Indianola (Iowa) | 802.68 mi (1,291.79 km) |
| Winston-Salem to Indio (California) | 2,033.04 mi (3,271.86 km) |
| Winston-Salem to Inglewood (California) | 2,146.03 mi (3,453.71 km) |
| Winston-Salem to Inkster (Michigan) | 457.83 mi (736.81 km) |
| Winston-Salem to Inver Grove Heights (Minnesota) | 901.23 mi (1,450.39 km) |
| Winston-Salem to Inwood (New York) | 470.80 mi (757.68 km) |
| Winston-Salem to Iona (Florida) | 669.90 mi (1,078.11 km) |
| Winston-Salem to Ionia (Michigan) | 539.52 mi (868.27 km) |
| Winston-Salem to Iowa City (Iowa) | 716.45 mi (1,153.01 km) |
| Winston-Salem to Irmo (South Carolina) | 148.01 mi (238.20 km) |
| Winston-Salem to Irondale (Alabama) | 403.63 mi (649.59 km) |
| Winston-Salem to Ironton (Ohio) | 214.02 mi (344.43 km) |
| Winston-Salem to Irvine (California) | 2,119.47 mi (3,410.96 km) |
| Winston-Salem to Irving (Texas) | 976.36 mi (1,571.30 km) |
