| Winston-Salem to Sacramento (California) | 2,251.24 mi (3,623.02 km) |
| Winston-Salem to Saddlebrooke (Arizona) | 1,756.46 mi (2,826.74 km) |
| Winston-Salem to Safety Harbor (Florida) | 577.13 mi (928.81 km) |
| Winston-Salem to Saginaw (Michigan) | 542.04 mi (872.34 km) |
| Winston-Salem to Saginaw (Texas) | 998.04 mi (1,606.19 km) |
| Winston-Salem to Sahuarita (Arizona) | 1,774.33 mi (2,855.51 km) |
| Winston-Salem to Saks (Alabama) | 357.28 mi (574.99 km) |
| Winston-Salem to Salem (Massachusetts) | 667.44 mi (1,074.14 km) |
| Winston-Salem to Salem (Ohio) | 333.30 mi (536.40 km) |
| Winston-Salem to Salem (Oregon) | 2,298.73 mi (3,699.46 km) |
| Winston-Salem to Salem (Virginia) | 82.56 mi (132.87 km) |
| Winston-Salem to Salem Lakes (Wisconsin) | 611.45 mi (984.04 km) |
| Winston-Salem to Salida (California) | 2,240.25 mi (3,605.33 km) |
| Winston-Salem to Salina (Kansas) | 968.44 mi (1,558.56 km) |
| Winston-Salem to Salinas (California) | 2,283.04 mi (3,674.19 km) |
