| Winston-Salem to Sanford (Florida) | 508.78 mi (818.80 km) |
| Winston-Salem to Sanford (Maine) | 713.70 mi (1,148.59 km) |
| Winston-Salem to Sanford (North Carolina) | 74.15 mi (119.33 km) |
| Winston-Salem to Sanger (California) | 2,170.20 mi (3,492.60 km) |
| Winston-Salem to Santa Ana (California) | 2,124.38 mi (3,418.86 km) |
| Winston-Salem to Santa Barbara (California) | 2,213.75 mi (3,562.68 km) |
| Winston-Salem to Santa Clara (California) | 2,292.14 mi (3,688.85 km) |
| Winston-Salem to Santa Clara (Oregon) | 2,304.62 mi (3,708.93 km) |
| Winston-Salem to Santa Clarita (California) | 2,146.39 mi (3,454.27 km) |
| Winston-Salem to Santa Cruz (California) | 2,300.86 mi (3,702.87 km) |
| Winston-Salem to Santa Fe (New Mexico) | 1,435.99 mi (2,311.00 km) |
| Winston-Salem to Santa Fe (Texas) | 977.61 mi (1,573.31 km) |
| Winston-Salem to Santa Fe Springs (California) | 2,130.85 mi (3,429.27 km) |
| Winston-Salem to Santa Maria (California) | 2,244.97 mi (3,612.93 km) |
| Winston-Salem to Santa Monica (California) | 2,152.40 mi (3,463.95 km) |
