| Winston-Salem to Santa Paula (California) | 2,178.90 mi (3,506.61 km) |
| Winston-Salem to Santa Rosa (California) | 2,318.68 mi (3,731.55 km) |
| Winston-Salem to Santaquin (Utah) | 1,727.50 mi (2,780.14 km) |
| Winston-Salem to Santee (California) | 2,091.26 mi (3,365.56 km) |
| Winston-Salem to Sapulpa (Oklahoma) | 883.79 mi (1,422.33 km) |
| Winston-Salem to Saraland (Alabama) | 579.25 mi (932.21 km) |
| Winston-Salem to Sarasota (Florida) | 620.16 mi (998.06 km) |
| Winston-Salem to Sarasota Springs (Florida) | 621.34 mi (999.95 km) |
| Winston-Salem to Saratoga (California) | 2,296.54 mi (3,695.93 km) |
| Winston-Salem to Saratoga Springs (New York) | 591.81 mi (952.43 km) |
| Winston-Salem to Saratoga Springs (Utah) | 1,733.50 mi (2,789.80 km) |
| Winston-Salem to Sartell (Minnesota) | 979.44 mi (1,576.25 km) |
| Winston-Salem to Satellite Beach (Florida) | 547.91 mi (881.77 km) |
| Winston-Salem to Sauk Rapids (Minnesota) | 976.00 mi (1,570.72 km) |
| Winston-Salem to Sault Ste. Marie (Michigan) | 747.91 mi (1,203.65 km) |
