| Winston-Salem to Scottsbluff (Nebraska) | 1,313.56 mi (2,113.96 km) |
| Winston-Salem to Scottsboro (Alabama) | 341.26 mi (549.20 km) |
| Winston-Salem to Scottsdale (Arizona) | 1,790.91 mi (2,882.19 km) |
| Winston-Salem to Scranton (Pennsylvania) | 442.00 mi (711.33 km) |
| Winston-Salem to Seabrook (Maryland) | 272.79 mi (439.01 km) |
| Winston-Salem to Seabrook (Texas) | 966.89 mi (1,556.06 km) |
| Winston-Salem to Seaford (New York) | 483.33 mi (777.84 km) |
| Winston-Salem to Seagoville (Texas) | 957.43 mi (1,540.84 km) |
| Winston-Salem to Seal Beach (California) | 2,134.56 mi (3,435.25 km) |
| Winston-Salem to Searcy (Arkansas) | 646.39 mi (1,040.27 km) |
| Winston-Salem to Seaside (California) | 2,294.18 mi (3,692.12 km) |
| Winston-Salem to SeaTac (Washington) | 2,271.28 mi (3,655.26 km) |
| Winston-Salem to Seattle (Washington) | 2,273.48 mi (3,658.81 km) |
| Winston-Salem to Sebastian (Florida) | 575.05 mi (925.45 km) |
| Winston-Salem to Sebring (Florida) | 600.07 mi (965.72 km) |
