| Winston-Salem to Seymour (Indiana) | 365.69 mi (588.52 km) |
| Winston-Salem to Seymour (Tennessee) | 196.60 mi (316.39 km) |
| Winston-Salem to Shady Hills (Florida) | 548.39 mi (882.54 km) |
| Winston-Salem to Shafter (California) | 2,168.04 mi (3,489.12 km) |
| Winston-Salem to Shaker Heights (Ohio) | 377.55 mi (607.61 km) |
| Winston-Salem to Shakopee (Minnesota) | 915.51 mi (1,473.38 km) |
| Winston-Salem to Sharon (Pennsylvania) | 354.76 mi (570.93 km) |
| Winston-Salem to Sharonville (Ohio) | 315.60 mi (507.91 km) |
| Winston-Salem to Shasta Lake (California) | 2,280.64 mi (3,670.34 km) |
| Winston-Salem to Shawnee (Kansas) | 820.77 mi (1,320.89 km) |
| Winston-Salem to Shawnee (Oklahoma) | 937.19 mi (1,508.26 km) |
| Winston-Salem to Sheboygan (Wisconsin) | 659.06 mi (1,060.65 km) |
| Winston-Salem to Shelby (North Carolina) | 91.34 mi (147.00 km) |
| Winston-Salem to Shelbyville (Indiana) | 383.21 mi (616.72 km) |
| Winston-Salem to Shelbyville (Kentucky) | 309.74 mi (498.48 km) |
