| Winston-Salem to Smithville (Missouri) | 813.33 mi (1,308.93 km) |
| Winston-Salem to Smyrna (Delaware) | 336.51 mi (541.56 km) |
| Winston-Salem to Smyrna (Georgia) | 286.29 mi (460.73 km) |
| Winston-Salem to Smyrna (Tennessee) | 350.12 mi (563.47 km) |
| Winston-Salem to Snellville (Georgia) | 262.63 mi (422.66 km) |
| Winston-Salem to Snoqualmie (Washington) | 2,250.49 mi (3,621.82 km) |
| Winston-Salem to Snyder (Texas) | 1,197.82 mi (1,927.71 km) |
| Winston-Salem to Socastee (South Carolina) | 181.37 mi (291.89 km) |
| Winston-Salem to Socorro (Texas) | 1,518.26 mi (2,443.41 km) |
| Winston-Salem to Soddy-Daisy (Tennessee) | 281.82 mi (453.55 km) |
| Winston-Salem to Solana Beach (California) | 2,103.68 mi (3,385.55 km) |
| Winston-Salem to Soledad (California) | 2,270.80 mi (3,654.49 km) |
| Winston-Salem to Solon (Ohio) | 370.54 mi (596.32 km) |
| Winston-Salem to Somers Point (New Jersey) | 380.44 mi (612.26 km) |
| Winston-Salem to Somerset (Kentucky) | 250.61 mi (403.32 km) |
