| Winston-Salem to Southchase (Florida) | 537.70 mi (865.35 km) |
| Winston-Salem to Southern Pines (North Carolina) | 79.19 mi (127.44 km) |
| Winston-Salem to Southfield (Michigan) | 468.59 mi (754.12 km) |
| Winston-Salem to Southgate (Michigan) | 450.07 mi (724.31 km) |
| Winston-Salem to Southlake (Texas) | 984.29 mi (1,584.07 km) |
| Winston-Salem to Spanaway (Washington) | 2,275.32 mi (3,661.77 km) |
| Winston-Salem to Spanish Fork (Utah) | 1,719.20 mi (2,766.78 km) |
| Winston-Salem to Spanish Lake (Missouri) | 575.94 mi (926.89 km) |
| Winston-Salem to Spanish Springs (Nevada) | 2,145.85 mi (3,453.41 km) |
| Winston-Salem to Sparks (Nevada) | 2,148.95 mi (3,458.39 km) |
| Winston-Salem to Spartanburg (South Carolina) | 123.15 mi (198.19 km) |
| Winston-Salem to Spearfish (South Dakota) | 1,363.37 mi (2,194.14 km) |
| Winston-Salem to Speedway (Indiana) | 413.88 mi (666.08 km) |
| Winston-Salem to Spencer (Iowa) | 927.97 mi (1,493.42 km) |
| Winston-Salem to Spokane (Washington) | 2,047.91 mi (3,295.80 km) |
