| Winston-Salem to St. Petersburg (Florida) | 591.14 mi (951.34 km) |
| Winston-Salem to St. Simons (Georgia) | 346.40 mi (557.47 km) |
| Winston-Salem to Stafford (Texas) | 992.87 mi (1,597.88 km) |
| Winston-Salem to Stallings (North Carolina) | 72.25 mi (116.27 km) |
| Winston-Salem to Stamford (Connecticut) | 500.07 mi (804.78 km) |
| Winston-Salem to Stanford (California) | 2,302.11 mi (3,704.89 km) |
| Winston-Salem to Stanton (California) | 2,129.41 mi (3,426.95 km) |
| Winston-Salem to Star (Idaho) | 1,973.63 mi (3,176.25 km) |
| Winston-Salem to Starkville (Mississippi) | 519.16 mi (835.51 km) |
| Winston-Salem to State College (Pennsylvania) | 349.02 mi (561.70 km) |
| Winston-Salem to Staten Island (New York) | 453.12 mi (729.22 km) |
| Winston-Salem to Statesboro (Georgia) | 267.59 mi (430.65 km) |
| Winston-Salem to Statesville (North Carolina) | 40.62 mi (65.38 km) |
| Winston-Salem to Staunton (Virginia) | 156.70 mi (252.19 km) |
| Winston-Salem to Steamboat Springs (Colorado) | 1,466.01 mi (2,359.31 km) |
